Overview of the scientific sessions of the conference.
Genetics of MHE / MO / HME.
Presenting study results, Hereditary Multiple Exostoses and Pain
Orthopaedics’ of MHE / MO / HME.
Use of fixators, MHE / MO / HME
Harish Hosalkar,#; John P. Dormans,+
Abstract of MHE Conference Workshop Orthopaedics
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia
Professor of Orthopaedic Surgery, University of Pennsylvania School of Medicine
Multiple hereditary exostosis (MHE) is an inherited disease causing the development of numerous
cartilaginous exostoses throughout the skeleton.
It is most commonly inherited as an autosomal dominant loss of function mutation of either the
EXT1 or EXT2 genes with almost complete penetrance. Common problems for children with MHE are
pain and tenderness due to compression of tendons and nerves by the exostoses, skeletal
deformity due to altered growth of long bones, cosmetic concerns, and rarely ischemic complication
due to compression of vascular structures. As a result, most children with MHE will undergo several
procedures for removal of painful or deforming lesions.
Orthopaedics of MHE / MO / HME everything you need to know is a patient and parent-friendly
guides that outlines the common skeletal manifestations of MHE. This extensive review addresses
the diagnostic tools including important features on clinical exam, characterization of lesions,
diagnostic work up including imaging features and histology. We have attempted to outline the
established patterns of involvement of MHE in various parts of the body i.e. mainly the skeletal
system and their possible treatment options.
A specific note is made in each subsection regarding what the parents should watch out for.
Finally a glossary of procedures and terminology is presented.
Abstract of MHE Conference Workshop Orthopaedics
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia
Professor of Orthopaedic Surgery, University of Pennsylvania School of Medicine
Multiple hereditary exostosis (MHE) is an inherited disease causing the development of numerous
cartilaginous exostoses throughout the skeleton.
It is most commonly inherited as an autosomal dominant loss of function mutation of either the
EXT1 or EXT2 genes with almost complete penetrance. Common problems for children with MHE are
pain and tenderness due to compression of tendons and nerves by the exostoses, skeletal
deformity due to altered growth of long bones, cosmetic concerns, and rarely ischemic complication
due to compression of vascular structures. As a result, most children with MHE will undergo several
procedures for removal of painful or deforming lesions.
Orthopaedics of MHE / MO / HME everything you need to know is a patient and parent-friendly
guides that outlines the common skeletal manifestations of MHE. This extensive review addresses
the diagnostic tools including important features on clinical exam, characterization of lesions,
diagnostic work up including imaging features and histology. We have attempted to outline the
established patterns of involvement of MHE in various parts of the body i.e. mainly the skeletal
system and their possible treatment options.
A specific note is made in each subsection regarding what the parents should watch out for.
Finally a glossary of procedures and terminology is presented.
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MHE 2005 Conference workshop
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Chronic pain and the need for treatment.
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Disclaimer: While many find the information useful, it is in no way a substitute for professional medical care.
The information provided here is for educational and informational purposes only. This website does not engage in the practice
of medicine. In all cases we recommend that you consult your own physician regarding any course of treatment or medicine.
The information provided here is for educational and informational purposes only. This website does not engage in the practice
of medicine. In all cases we recommend that you consult your own physician regarding any course of treatment or medicine.
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This web page was updated last on 2/20/08, 4:00 pm Eastern time
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National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
By the Health On the Net Foundation. Click here to verify.# HON Conduct 282463 and is linked on the NIH
National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
The MHE Research Foundation is proud to be working with the EuroBoNeT consortium, a European Commission
granted Network of Excellence for studying the pathology and genetics of bone tumors.
granted Network of Excellence for studying the pathology and genetics of bone tumors.
