Dr. Esko serves on the Scientific and Medical Advisory Board of the MHE Research Foundation and was past
president of the
Society of Glycobiology
Research authored by Dr. Esko
Click the tab and a window will appear.
List of Publications via PubMed
(NIH National Library of Medicine)
Jeffrey D. Esko Ph.D. research
Questions to the Scientific & Medical Advisory Board,
Please use the contact Scientific & Medical Advisory Board Tab or you may email directly

Have a Question  or  Comments for the Board of Directors,  
Please use the contact Board of Directors Tab or General enquiries can be emailed to

Be notified of page updates
it's private

Home page
Wings of HOPE as we REACH
for the CURE to
Multiple Hereditary Exostoses Syndrome
Multiple Osteochondroma Syndrome
Jeffrey D. Esko, Ph.D.
Professor, Department of Cellular and Molecular Medicine
Co-Director, Glycobiology Research & Training Center
University of California, San Diego, School of Medicine
Esko lab website page

Research in Dr. Esko’s laboratory focuses on the structure, biosynthesis, and function of proteoglycans. Current work includes
structural studies of heparan sulfate by mass spectrometry; studies of 3-O-sulfation of heparan sulfate; application of genome-
wide methods to identify novel genes involved in heparan sulfate assembly; analysis of guanidinylated glycosides that bind to
proteoglycans and facilitate delivery of high molecular weight cargo into the interior of the cell; studies of proteoglycans in
lipoprotein metabolism; and studies on the role of proteoglycans in inflammation. His lab has extensive experience in the
isolation and characterization of glycosaminoglycans, selection and characterization of mutant cell lines altered in
glycosaminoglycan metabolism, and development of genetic models altered in glycosaminoglycan metabolism in mice.

Several studies in his lab focus specifically on Hereditary Multiple Exostoses. Early on his group characterized heparan sulfate-
deficient cell lines and demonstrated genetically that alteration of Ext1 affected the copolymerization of heparan sulfate in vivo
and in vitro. He also mapped the glucuronosyltransferase domain in Ext1. His group characterized Ext1 and Ext2 deficient mice,
and were the first group to demonstrate that the animals develop exostoses on the ribs. Subsequent studies have shown that
the formation of exostoses exhibits gene dosage effects and that the exostoses originate from cells of the chondrocyte
lineage. Ongoing work is focused on developing therapeutic approaches for treating the disease. Dr. Esko is one of The MHE
Research Foundation members of the Scientific and Medical  Board A co-chaired the first conference sponsored by the MHE
Research Foundation, and will organize and chair the next meeting in 2015.  

Written consent must be obtained to attach web pages or the files attached to this website, please email the webmaster.

Email the webmaster:
Materials on this website are protected by copyright
Copyright © 2014 The MHE Research Foundation

Disclaimer:   While many find the information useful, it is in no way a substitute for professional medical care.
The information provided here is for educational and informational purposes only. This website does not engage in the practice of medicine.
In all cases we recommend that you consult your own physician regarding any course of treatment or medicine.

This web page was updated last on 3/16/14, 12:0O pm Eastern time
The MHE Research Foundation, we comply with the HONcode standard for health trust worthy information: By the Health On the Net Foundation.      
here to verify.# HON Conduct 282463  and is the patient support link on the US Government Genetics Home Reference (http://ghr.nlm.nih.gov)
website, also linked for Patient Information on
The Diseases Database a cross-referenced index of human disease, as well as the
Intute: health & life sciences  a free online service  providing access to the very best Web resources for education and research located in the  UK
This website is regularly reviewed by members of the Scientific and Medical Advisory Board of the MHE Research Foundation.

All online submission forms use (SSL AES 256 bit encryption (High); RSA 1024 bit exchange) Protocol with
Privacy protection.
Our goal is to make this website as safe and user friendly as possible.
The MHE Research Foundation is a participating member organization of the
United States Bone and Joint Decade/Initiative,  (USBJD/I) & the  USBJD/I Rare Bone Disease Patient Network
number of users on this website page now :

The MHE Research Foundation is proud to be an affiliate of the Society For Glycobiology
The MHE Research Foundationis proud to be a partnering society with ASMB  / MSTS  / CTOS