FISH-metaphase: A technique used to identify the presence of specific chromosomes or
chromosomal regions through hybridization (attachment) of fluorescently-labeled DNA probes to
denatured chromosomal DNA. Examination under fluorescent lighting detects the presence of the
hybridized fluorescent signal (and hence presence of the chromosome material) or absence of the
hybridized fluorescent signal (and hence absence of the chromosome material). With metaphase
FISH, cells progress through the division process until metaphase, when chromosomes are
condensed and can be individually distinguished. In contrast to interphase FISH, metaphase FISH
permits visualization of the actual chromosomes as well as the general location of the abnormality on
the chromosome.
chromosomal regions through hybridization (attachment) of fluorescently-labeled DNA probes to
denatured chromosomal DNA. Examination under fluorescent lighting detects the presence of the
hybridized fluorescent signal (and hence presence of the chromosome material) or absence of the
hybridized fluorescent signal (and hence absence of the chromosome material). With metaphase
FISH, cells progress through the division process until metaphase, when chromosomes are
condensed and can be individually distinguished. In contrast to interphase FISH, metaphase FISH
permits visualization of the actual chromosomes as well as the general location of the abnormality on
the chromosome.
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| FISH Testing |
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National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
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