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Xinhua Lin, Ph.D.
Division of Developmental Biology
Cincinnati Children's Hospital Medical Center
Our laboratory is interested in cell-cell signaling mechanisms that control normal development and disease processes. Our
studies cover several fields including Developmental Biology, Genetics, Cell Biology,
Cancer Biology and Neurobiology.
We utilize genetic, molecular and cell biological approaches in model organism fruit fly (Drosophila) and in tissue culture system
to address our defined questions.
During embryonic development, the coordinated growth and patterning of multi-cellular organisms is controlled by a relatively
small number of signaling molecules including Wnt, Hedgehog (Hh), BMP and FGF. These signaling molecules act as morphogens
whose concentration gradients provide positional information to pattern tissues.
Deregulation of these factors and their signaling pathways are associated with numerous human diseases including cancers.
Over past decades, intensive molecular and genetic studies have elucidated central components of these signaling pathways.
However, it is less known about how the gradients of these molecules are regulated and how the identified intracellular signaling
components are controlled by cellular machinery to execute their signaling activities.
Heparan sulfate proteoglycans (HSPGs) are cell surface and extracellular matrix macromolecules that are composed of a core
protein decorated with covalently linked glycosaminoglycan (GAG) chains. Biochemical and cell culture studies have
demonstrated essential roles of these molecules in many cellular functions including intercellular signaling. Recent studies in
animal model systems have begun to clarify their essential functions in development. We and others have shown that HSPGs
play critical roles in regulating Wnt, Hh, BMP and FGF signaling pathways.
The long-term goal of our research is to elucidate the mechanisms by which the gradients of morphogens are established and
interpreted into transcription outputs during development. In particular, we are interested in the role of HSPGs in morphogen
gradient formation and morphogenesis.
Division of Developmental Biology
Cincinnati Children's Hospital Medical Center
Our laboratory is interested in cell-cell signaling mechanisms that control normal development and disease processes. Our
studies cover several fields including Developmental Biology, Genetics, Cell Biology,
Cancer Biology and Neurobiology.
We utilize genetic, molecular and cell biological approaches in model organism fruit fly (Drosophila) and in tissue culture system
to address our defined questions.
During embryonic development, the coordinated growth and patterning of multi-cellular organisms is controlled by a relatively
small number of signaling molecules including Wnt, Hedgehog (Hh), BMP and FGF. These signaling molecules act as morphogens
whose concentration gradients provide positional information to pattern tissues.
Deregulation of these factors and their signaling pathways are associated with numerous human diseases including cancers.
Over past decades, intensive molecular and genetic studies have elucidated central components of these signaling pathways.
However, it is less known about how the gradients of these molecules are regulated and how the identified intracellular signaling
components are controlled by cellular machinery to execute their signaling activities.
Heparan sulfate proteoglycans (HSPGs) are cell surface and extracellular matrix macromolecules that are composed of a core
protein decorated with covalently linked glycosaminoglycan (GAG) chains. Biochemical and cell culture studies have
demonstrated essential roles of these molecules in many cellular functions including intercellular signaling. Recent studies in
animal model systems have begun to clarify their essential functions in development. We and others have shown that HSPGs
play critical roles in regulating Wnt, Hh, BMP and FGF signaling pathways.
The long-term goal of our research is to elucidate the mechanisms by which the gradients of morphogens are established and
interpreted into transcription outputs during development. In particular, we are interested in the role of HSPGs in morphogen
gradient formation and morphogenesis.
Research authored by Dr. Lin
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List of Publications via PubMed
(NIH National Library of Medicine)
List of Publications via PubMed
(NIH National Library of Medicine)
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