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Xinhua Lin, Ph.D.
Division of Developmental Biology
Cincinnati Children's Hospital Medical Center
Our laboratory is interested in cell-cell signaling mechanisms that control normal development and
disease processes. Our studies cover several fields including Developmental Biology, Genetics, Cell
Biology,
Cancer Biology and Neurobiology.
We utilize genetic, molecular and cell biological approaches in model organism fruit fly (Drosophila)
and in tissue culture system to address our defined questions.
During embryonic development, the coordinated growth and patterning of multi-cellular organisms is
controlled by a relatively small number of signaling molecules including Wnt, Hedgehog (Hh), BMP and
FGF. These signaling molecules act as morphogens whose concentration gradients provide positional
information to pattern tissues.
Deregulation of these factors and their signaling pathways are associated with numerous human
diseases including cancers. Over past decades, intensive molecular and genetic studies have
elucidated central components of these signaling pathways. However, it is less known about how the
gradients of these molecules are regulated and how the identified intracellular signaling components
are controlled by cellular machinery to execute their signaling activities.
Heparan sulfate proteoglycans (HSPGs) are cell surface and extracellular matrix macromolecules that
are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains.
Biochemical and cell culture studies have demonstrated essential roles of these molecules in many
cellular functions including intercellular signaling. Recent studies in animal model systems have begun
to clarify their essential functions in development. We and others have shown that HSPGs play
critical roles in regulating Wnt, Hh, BMP and FGF signaling pathways.
The long-term goal of our research is to elucidate the mechanisms by which the gradients of
morphogens are established and interpreted into transcription outputs during development. In
particular, we are interested in the role of HSPGs in morphogen gradient formation and
morphogenesis.
Division of Developmental Biology
Cincinnati Children's Hospital Medical Center
Our laboratory is interested in cell-cell signaling mechanisms that control normal development and
disease processes. Our studies cover several fields including Developmental Biology, Genetics, Cell
Biology,
Cancer Biology and Neurobiology.
We utilize genetic, molecular and cell biological approaches in model organism fruit fly (Drosophila)
and in tissue culture system to address our defined questions.
During embryonic development, the coordinated growth and patterning of multi-cellular organisms is
controlled by a relatively small number of signaling molecules including Wnt, Hedgehog (Hh), BMP and
FGF. These signaling molecules act as morphogens whose concentration gradients provide positional
information to pattern tissues.
Deregulation of these factors and their signaling pathways are associated with numerous human
diseases including cancers. Over past decades, intensive molecular and genetic studies have
elucidated central components of these signaling pathways. However, it is less known about how the
gradients of these molecules are regulated and how the identified intracellular signaling components
are controlled by cellular machinery to execute their signaling activities.
Heparan sulfate proteoglycans (HSPGs) are cell surface and extracellular matrix macromolecules that
are composed of a core protein decorated with covalently linked glycosaminoglycan (GAG) chains.
Biochemical and cell culture studies have demonstrated essential roles of these molecules in many
cellular functions including intercellular signaling. Recent studies in animal model systems have begun
to clarify their essential functions in development. We and others have shown that HSPGs play
critical roles in regulating Wnt, Hh, BMP and FGF signaling pathways.
The long-term goal of our research is to elucidate the mechanisms by which the gradients of
morphogens are established and interpreted into transcription outputs during development. In
particular, we are interested in the role of HSPGs in morphogen gradient formation and
morphogenesis.
Research authored by Dr. Lin
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List of Publications via PubMed
(NIH National Library of Medicine)
List of Publications via PubMed
(NIH National Library of Medicine)
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National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
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