Research authored by Dr. Hosalkar
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List of Publications via PubMed
(NIH National Library of Medicine)
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List of Publications via PubMed
(NIH National Library of Medicine)
| Dr. Hosalkar |
Harish Hosalkar,#; John P. Dormans,+
Abstract of MHE Conference Workshop Orthopaedics
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia
Professor of Orthopaedic Surgery, University of Pennsylvania School of Medicine
Multiple hereditary exostosis (MHE) is an inherited disease causing the development of numerous cartilaginous exostoses
throughout the skeleton.
It is most commonly inherited as an autosomal dominant loss of function mutation of either the EXT1 or EXT2 genes with
almost complete penetrance. Common problems for children with MHE are pain and tenderness due to compression of tendons
and nerves by the exostoses, skeletal deformity due to altered growth of long bones, cosmetic concerns, and rarely ischemic
complication due to compression of vascular structures. As a result, most children with MHE will undergo several procedures for
removal of painful or deforming lesions.
Orthopaedics of MHE / MO / HME everything you need to know is a patient and parent-friendly guides that outlines the common
skeletal manifestations of MHE. This extensive review addresses the diagnostic tools including important features on clinical
exam, characterization of lesions, diagnostic work up including imaging features and histology. We have attempted to outline
the established patterns of involvement of MHE in various parts of the body i.e. mainly the skeletal system and their possible
treatment options. A specific note is made in each subsection regarding what the parents should watch out for. Finally a
glossary of procedures and terminology is presented.
Abstract of MHE Conference Workshop Orthopaedics
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia
Professor of Orthopaedic Surgery, University of Pennsylvania School of Medicine
Multiple hereditary exostosis (MHE) is an inherited disease causing the development of numerous cartilaginous exostoses
throughout the skeleton.
It is most commonly inherited as an autosomal dominant loss of function mutation of either the EXT1 or EXT2 genes with
almost complete penetrance. Common problems for children with MHE are pain and tenderness due to compression of tendons
and nerves by the exostoses, skeletal deformity due to altered growth of long bones, cosmetic concerns, and rarely ischemic
complication due to compression of vascular structures. As a result, most children with MHE will undergo several procedures for
removal of painful or deforming lesions.
Orthopaedics of MHE / MO / HME everything you need to know is a patient and parent-friendly guides that outlines the common
skeletal manifestations of MHE. This extensive review addresses the diagnostic tools including important features on clinical
exam, characterization of lesions, diagnostic work up including imaging features and histology. We have attempted to outline
the established patterns of involvement of MHE in various parts of the body i.e. mainly the skeletal system and their possible
treatment options. A specific note is made in each subsection regarding what the parents should watch out for. Finally a
glossary of procedures and terminology is presented.
Press Release 04 / 09 / 07 4pm Eastern time
Abnormal Scarring With Keloid Formation After Osteochondroma Excision in Children With Multiple Hereditary
Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007.
To read the abstract from this research paper Click Here
Harish Hosalkar, MD, MBMS (Ortho), FCPS (Ortho), DNB (Ortho); Jared Greenberg, MD; Rebecca L. Gaugler, BS;
Sumeet Garg, MD; John P. Dormans, MD
Discussion: Abnormal scarring with keloid formation after osteochondroma excision in MHE has not been previously reported.
Although this study has limited numbers, the results demonstrate a statistically significant correlation between keloid formation
and MHE. The risk for abnormal scarring and keloid formation should be discussed with all patients before surgery.
Abstract 2005 MHE Conference
Keloid Formation Following Surgical Treatment of Multiple Hereditary Exostoses
Harish Hosalkar, MD#; John P. Dormans, MD+
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Professor of Orthopaedic Surgery, University
of Pennsylvania School of Medicine
Introduction: Multiple hereditary exostoses (MHE) is an autosomal dominant trait characterized by numerous cartilage capped
tumors in areas of actively growing bone. The formation of keloids following surgery for MHE has not previously been described.
Methods: A retrospective case-controlled study was undertaken to test the hypothesis that patients with MHE are at higher
risk for keloid formation following excision of an exostosis. The study population consisted of a study group of 25 children and
adolescent cases of MHE randomly selected from a tumor database at our institution and a control group of 25 age-matched
cases of solitary exostosis (osteochondroma). All patients participated in a phone interview that consisted of questions
regarding the number of surgeries, recurrence of lesions, wound healing problems, keloid formation, keloid site and dimensions,
and any revision surgery. All patients with wound healing problems or suspected keloids were asked to take clinical pictures and
mail them in. Based on clinical criteria these cases were identified as keloids or non-keloids.
Results: 83 surgeries were performed in 25 patients with MHE for primary excision of their exostoses. 25 surgeries were
performed in 25 cases of solitary exostoses. 12 keloids formed in 7 patients in the MHE study group. No patients who
underwent excision of solitary exostoses formed keloids. Diagnosis of MHE was a statistically significant risk factor for formation
of keloids following surgery (p<.05). Maximal keloid width ranged from 5-10cm. Scar revision was performed in four of the
seven children with keloid formation with MHE, of whom two required additional scar revision procedures.
Abnormal Scarring With Keloid Formation After Osteochondroma Excision in Children With Multiple Hereditary
Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007.
To read the abstract from this research paper Click Here
Harish Hosalkar, MD, MBMS (Ortho), FCPS (Ortho), DNB (Ortho); Jared Greenberg, MD; Rebecca L. Gaugler, BS;
Sumeet Garg, MD; John P. Dormans, MD
Discussion: Abnormal scarring with keloid formation after osteochondroma excision in MHE has not been previously reported.
Although this study has limited numbers, the results demonstrate a statistically significant correlation between keloid formation
and MHE. The risk for abnormal scarring and keloid formation should be discussed with all patients before surgery.
Abstract 2005 MHE Conference
Keloid Formation Following Surgical Treatment of Multiple Hereditary Exostoses
Harish Hosalkar, MD#; John P. Dormans, MD+
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Professor of Orthopaedic Surgery, University
of Pennsylvania School of Medicine
Introduction: Multiple hereditary exostoses (MHE) is an autosomal dominant trait characterized by numerous cartilage capped
tumors in areas of actively growing bone. The formation of keloids following surgery for MHE has not previously been described.
Methods: A retrospective case-controlled study was undertaken to test the hypothesis that patients with MHE are at higher
risk for keloid formation following excision of an exostosis. The study population consisted of a study group of 25 children and
adolescent cases of MHE randomly selected from a tumor database at our institution and a control group of 25 age-matched
cases of solitary exostosis (osteochondroma). All patients participated in a phone interview that consisted of questions
regarding the number of surgeries, recurrence of lesions, wound healing problems, keloid formation, keloid site and dimensions,
and any revision surgery. All patients with wound healing problems or suspected keloids were asked to take clinical pictures and
mail them in. Based on clinical criteria these cases were identified as keloids or non-keloids.
Results: 83 surgeries were performed in 25 patients with MHE for primary excision of their exostoses. 25 surgeries were
performed in 25 cases of solitary exostoses. 12 keloids formed in 7 patients in the MHE study group. No patients who
underwent excision of solitary exostoses formed keloids. Diagnosis of MHE was a statistically significant risk factor for formation
of keloids following surgery (p<.05). Maximal keloid width ranged from 5-10cm. Scar revision was performed in four of the
seven children with keloid formation with MHE, of whom two required additional scar revision procedures.
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Click here to verify.# HON Conduct 282463 and is the patient support link on the US Government Genetics Home Reference (http://ghr.nlm.nih.gov)
website, also linked for Patient Information on The Diseases Database a cross-referenced index of human disease, as well as the
Intute: health & life sciences a free online service providing access to the very best Web resources for education and research located in the UK
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