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Dr. Dormans serves on the Scientific and Medical Advisory Board of the MHE Research Foundation
Research authored by Dr. Dormans
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List of Publications via PubMed
(NIH National Library of Medicine)
Research authored by Dr. Dormans
Click the tab and a window will appear.
List of Publications via PubMed
(NIH National Library of Medicine)
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Questions to the Scientific & Medical Advisory Board,
Please use the contact Scientific & Medical Advisory Board Tab or you may email directly
AdvisoryBoard@mheresearchfoundation.org
Please use the contact Scientific & Medical Advisory Board Tab or you may email directly
AdvisoryBoard@mheresearchfoundation.org
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Have a Question or Comments for the Board of Directors,
Please use the contact Board of Directors Tab or General enquiries can be emailed to
Boardofdirectors@mheresearchfoundation.org
Please use the contact Board of Directors Tab or General enquiries can be emailed to
Boardofdirectors@mheresearchfoundation.org
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Media Spokesperson American Academy of Orthopaedic Surgeons
http://www6.aaos.org/news/pemr/spokes/List_detail.cfm?encrypted=%24%2D%5ET7%24%40%20%20%0A
http://www6.aaos.org/news/pemr/spokes/List_detail.cfm?encrypted=%24%2D%5ET7%24%40%20%20%0A
Harish Hosalkar,#; John P. Dormans,+
Abstract of MHE Conference Workshop Orthopaedics
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia
Professor of Orthopaedic Surgery, University of Pennsylvania School of Medicine
Multiple hereditary exostosis (MHE) is an inherited disease causing the development of numerous
cartilaginous exostoses throughout the skeleton.
It is most commonly inherited as an autosomal dominant loss of function mutation of either the
EXT1 or EXT2 genes with almost complete penetrance. Common problems for children with MHE are
pain and tenderness due to compression of tendons and nerves by the exostoses, skeletal
deformity due to altered growth of long bones, cosmetic concerns, and rarely ischemic complication
due to compression of vascular structures. As a result, most children with MHE will undergo several
procedures for removal of painful or deforming lesions.
Orthopaedics of MHE / MO / HME everything you need to know is a patient and parent-friendly
guides that outlines the common skeletal manifestations of MHE. This extensive review addresses
the diagnostic tools including important features on clinical exam, characterization of lesions,
diagnostic work up including imaging features and histology. We have attempted to outline the
established patterns of involvement of MHE in various parts of the body i.e. mainly the skeletal
system and their possible treatment options. A specific note is made in each subsection regarding
what the parents should watch out for. Finally a glossary of procedures and terminology is
presented.
Abstract of MHE Conference Workshop Orthopaedics
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia
Professor of Orthopaedic Surgery, University of Pennsylvania School of Medicine
Multiple hereditary exostosis (MHE) is an inherited disease causing the development of numerous
cartilaginous exostoses throughout the skeleton.
It is most commonly inherited as an autosomal dominant loss of function mutation of either the
EXT1 or EXT2 genes with almost complete penetrance. Common problems for children with MHE are
pain and tenderness due to compression of tendons and nerves by the exostoses, skeletal
deformity due to altered growth of long bones, cosmetic concerns, and rarely ischemic complication
due to compression of vascular structures. As a result, most children with MHE will undergo several
procedures for removal of painful or deforming lesions.
Orthopaedics of MHE / MO / HME everything you need to know is a patient and parent-friendly
guides that outlines the common skeletal manifestations of MHE. This extensive review addresses
the diagnostic tools including important features on clinical exam, characterization of lesions,
diagnostic work up including imaging features and histology. We have attempted to outline the
established patterns of involvement of MHE in various parts of the body i.e. mainly the skeletal
system and their possible treatment options. A specific note is made in each subsection regarding
what the parents should watch out for. Finally a glossary of procedures and terminology is
presented.
Press Release 04 / 09 / 07 4pm Eastern time
Abnormal Scarring With Keloid Formation After Osteochondroma Excision in Children With
Multiple Hereditary Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007.
To read the abstract from this research paper Click Here
Harish Hosalkar, MD, MBMS (Ortho), FCPS (Ortho), DNB (Ortho); Jared Greenberg, MD;
Rebecca L. Gaugler, BS; Sumeet Garg, MD; John P. Dormans, MD
Discussion: Abnormal scarring with keloid formation after osteochondroma excision in MHE has not
been previously reported. Although this study has limited numbers, the results demonstrate a
statistically significant correlation between keloid formation and MHE. The risk for abnormal scarring
and keloid formation should be discussed with all patients before surgery.
Abstract 2005 MHE Conference
Keloid Formation Following Surgical Treatment of Multiple Hereditary Exostoses
Harish Hosalkar, MD#; John P. Dormans, MD+
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Professor of
Orthopaedic Surgery, University of Pennsylvania School of Medicine
Introduction: Multiple hereditary exostoses (MHE) is an autosomal dominant trait characterized by
numerous cartilage capped tumors in areas of actively growing bone. The formation of keloids
following surgery for MHE has not previously been described.
Methods: A retrospective case-controlled study was undertaken to test the hypothesis that
patients with MHE are at higher risk for keloid formation following excision of an exostosis. The
study population consisted of a study group of 25 children and adolescent cases of MHE randomly
selected from a tumor database at our institution and a control group of 25 age-matched cases of
solitary exostosis (osteochondroma). All patients participated in a phone interview that consisted of
questions regarding the number of surgeries, recurrence of lesions, wound healing problems, keloid
formation, keloid site and dimensions, and any revision surgery. All patients with wound healing
problems or suspected keloids were asked to take clinical pictures and mail them in. Based on clinical
criteria these cases were identified as keloids or non-keloids.
Results: 83 surgeries were performed in 25 patients with MHE for primary excision of their
exostoses. 25 surgeries were performed in 25 cases of solitary exostoses. 12 keloids formed in 7
patients in the MHE study group. No patients who underwent excision of solitary exostoses formed
keloids. Diagnosis of MHE was a statistically significant risk factor for formation of keloids following
surgery (p<.05). Maximal keloid width ranged from 5-10cm. Scar revision was performed in four of
the seven children with keloid formation with MHE, of whom two required additional scar revision
procedures.
Abnormal Scarring With Keloid Formation After Osteochondroma Excision in Children With
Multiple Hereditary Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007.
To read the abstract from this research paper Click Here
Harish Hosalkar, MD, MBMS (Ortho), FCPS (Ortho), DNB (Ortho); Jared Greenberg, MD;
Rebecca L. Gaugler, BS; Sumeet Garg, MD; John P. Dormans, MD
Discussion: Abnormal scarring with keloid formation after osteochondroma excision in MHE has not
been previously reported. Although this study has limited numbers, the results demonstrate a
statistically significant correlation between keloid formation and MHE. The risk for abnormal scarring
and keloid formation should be discussed with all patients before surgery.
Abstract 2005 MHE Conference
Keloid Formation Following Surgical Treatment of Multiple Hereditary Exostoses
Harish Hosalkar, MD#; John P. Dormans, MD+
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Professor of
Orthopaedic Surgery, University of Pennsylvania School of Medicine
Introduction: Multiple hereditary exostoses (MHE) is an autosomal dominant trait characterized by
numerous cartilage capped tumors in areas of actively growing bone. The formation of keloids
following surgery for MHE has not previously been described.
Methods: A retrospective case-controlled study was undertaken to test the hypothesis that
patients with MHE are at higher risk for keloid formation following excision of an exostosis. The
study population consisted of a study group of 25 children and adolescent cases of MHE randomly
selected from a tumor database at our institution and a control group of 25 age-matched cases of
solitary exostosis (osteochondroma). All patients participated in a phone interview that consisted of
questions regarding the number of surgeries, recurrence of lesions, wound healing problems, keloid
formation, keloid site and dimensions, and any revision surgery. All patients with wound healing
problems or suspected keloids were asked to take clinical pictures and mail them in. Based on clinical
criteria these cases were identified as keloids or non-keloids.
Results: 83 surgeries were performed in 25 patients with MHE for primary excision of their
exostoses. 25 surgeries were performed in 25 cases of solitary exostoses. 12 keloids formed in 7
patients in the MHE study group. No patients who underwent excision of solitary exostoses formed
keloids. Diagnosis of MHE was a statistically significant risk factor for formation of keloids following
surgery (p<.05). Maximal keloid width ranged from 5-10cm. Scar revision was performed in four of
the seven children with keloid formation with MHE, of whom two required additional scar revision
procedures.
This website is regularly reviewed by members of the Scientific and Medical Advisory Board of the MHE Research Foundation.
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By the Health On the Net Foundation. Click here to verify.# HON Conduct 282463 and is linked on the NIH
National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
The MHE Research Foundation is proud to be working with the EuroBoNeT consortium, a European Commission
granted Network of Excellence for studying the pathology and genetics of bone tumors.
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