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Dr. Dormans serves on the Scientific and Medical Advisory Board of the MHE Research Foundation
Research authored by Dr. Dormans
Click the tab and a window will appear.
List of Publications via PubMed
(NIH National Library of Medicine)
Research authored by Dr. Dormans
Click the tab and a window will appear.
List of Publications via PubMed
(NIH National Library of Medicine)
| Dr. John P. Dormans |
Questions to the Scientific & Medical Advisory Board,
Please use the contact Scientific & Medical Advisory Board Tab or you may email directly
AdvisoryBoard@mheresearchfoundation.org
Please use the contact Scientific & Medical Advisory Board Tab or you may email directly
AdvisoryBoard@mheresearchfoundation.org
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Have a Question or Comments for the Board of Directors,
Please use the contact Board of Directors Tab or General enquiries can be emailed to
Boardofdirectors@mheresearchfoundation.org
Please use the contact Board of Directors Tab or General enquiries can be emailed to
Boardofdirectors@mheresearchfoundation.org
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Harish Hosalkar,#; John P. Dormans,+
Abstract of MHE Conference Workshop Orthopaedics
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia
Professor of Orthopaedic Surgery, University of Pennsylvania School of Medicine
Multiple hereditary exostoses (MHE) is an inherited disease causing the development of numerous cartilaginous exostoses
throughout the skeleton.
It is most commonly inherited as an autosomal dominant loss of function mutation of either the EXT1 or EXT2 genes with
almost complete penetrance. Common problems for children with MHE are pain and tenderness due to compression of tendons
and nerves by the exostoses, skeletal deformity due to altered growth of long bones, cosmetic concerns, and rarely ischemic
complication due to compression of vascular structures. As a result, most children with MHE will undergo several procedures for
removal of painful or deforming lesions.
Orthopaedics of MHE / MO / HME everything you need to know is a patient and parent-friendly guides that outlines the common
skeletal manifestations of MHE. This extensive review addresses the diagnostic tools including important features on clinical
exam, characterization of lesions, diagnostic work up including imaging features and histology. We have attempted to outline
the established patterns of involvement of MHE in various parts of the body i.e. mainly the skeletal system and their possible
treatment options. A specific note is made in each subsection regarding what the parents should watch out for. Finally a
glossary of procedures and terminology is presented.
Abstract of MHE Conference Workshop Orthopaedics
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia
Professor of Orthopaedic Surgery, University of Pennsylvania School of Medicine
Multiple hereditary exostoses (MHE) is an inherited disease causing the development of numerous cartilaginous exostoses
throughout the skeleton.
It is most commonly inherited as an autosomal dominant loss of function mutation of either the EXT1 or EXT2 genes with
almost complete penetrance. Common problems for children with MHE are pain and tenderness due to compression of tendons
and nerves by the exostoses, skeletal deformity due to altered growth of long bones, cosmetic concerns, and rarely ischemic
complication due to compression of vascular structures. As a result, most children with MHE will undergo several procedures for
removal of painful or deforming lesions.
Orthopaedics of MHE / MO / HME everything you need to know is a patient and parent-friendly guides that outlines the common
skeletal manifestations of MHE. This extensive review addresses the diagnostic tools including important features on clinical
exam, characterization of lesions, diagnostic work up including imaging features and histology. We have attempted to outline
the established patterns of involvement of MHE in various parts of the body i.e. mainly the skeletal system and their possible
treatment options. A specific note is made in each subsection regarding what the parents should watch out for. Finally a
glossary of procedures and terminology is presented.
Press Release 04 / 09 / 07 4pm Eastern time
Abnormal Scarring With Keloid Formation After Osteochondroma Excision in Children With Multiple Hereditary
Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007.
To read the abstract from this research paper Click Here
Harish Hosalkar, MD, MBMS (Ortho), FCPS (Ortho), DNB (Ortho); Jared Greenberg, MD; Rebecca L. Gaugler, BS;
Sumeet Garg, MD; John P. Dormans, MD
Discussion: Abnormal scarring with keloid formation after osteochondroma excision in MHE has not been previously reported.
Although this study has limited numbers, the results demonstrate a statistically significant correlation between keloid formation
and MHE. The risk for abnormal scarring and keloid formation should be discussed with all patients before surgery.
Abstract 2005 MHE Conference
Keloid Formation Following Surgical Treatment of Multiple Hereditary Exostoses
Harish Hosalkar, MD#; John P. Dormans, MD+
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Professor of Orthopaedic Surgery,
University of Pennsylvania School of Medicine
Introduction: Multiple hereditary exostoses (MHE) is an autosomal dominant trait characterized by numerous cartilage capped
tumors in areas of actively growing bone. The formation of keloids following surgery for MHE has not previously been described.
Methods: A retrospective case-controlled study was undertaken to test the hypothesis that patients with MHE are at higher
risk for keloid formation following excision of an exostosis. The study population consisted of a study group of 25 children and
adolescent cases of MHE randomly selected from a tumor database at our institution and a control group of 25 age-matched
cases of solitary exostosis (osteochondroma). All patients participated in a phone interview that consisted of questions
regarding the number of surgeries, recurrence of lesions, wound healing problems, keloid formation, keloid site and dimensions,
and any revision surgery. All patients with wound healing problems or suspected keloids were asked to take clinical pictures and
mail them in. Based on clinical criteria these cases were identified as keloids or non-keloids.
Results: 83 surgeries were performed in 25 patients with MHE for primary excision of their exostoses. 25 surgeries were
performed in 25 cases of solitary exostoses. 12 keloids formed in 7 patients in the MHE study group. No patients who
underwent excision of solitary exostoses formed keloids. Diagnosis of MHE was a statistically significant risk factor for
formation of keloids following surgery (p<.05). Maximal keloid width ranged from 5-10cm. Scar revision was performed in four
of the seven children with keloid formation with MHE, of whom two required additional scar revision procedures.
Abnormal Scarring With Keloid Formation After Osteochondroma Excision in Children With Multiple Hereditary
Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007.
To read the abstract from this research paper Click Here
Harish Hosalkar, MD, MBMS (Ortho), FCPS (Ortho), DNB (Ortho); Jared Greenberg, MD; Rebecca L. Gaugler, BS;
Sumeet Garg, MD; John P. Dormans, MD
Discussion: Abnormal scarring with keloid formation after osteochondroma excision in MHE has not been previously reported.
Although this study has limited numbers, the results demonstrate a statistically significant correlation between keloid formation
and MHE. The risk for abnormal scarring and keloid formation should be discussed with all patients before surgery.
Abstract 2005 MHE Conference
Keloid Formation Following Surgical Treatment of Multiple Hereditary Exostoses
Harish Hosalkar, MD#; John P. Dormans, MD+
#Orthopaedic Resident, The Children’s Hospital of Philadelphia
+Chief of Orthopaedic Surgery, The Children’s Hospital of Philadelphia, Professor of Orthopaedic Surgery,
University of Pennsylvania School of Medicine
Introduction: Multiple hereditary exostoses (MHE) is an autosomal dominant trait characterized by numerous cartilage capped
tumors in areas of actively growing bone. The formation of keloids following surgery for MHE has not previously been described.
Methods: A retrospective case-controlled study was undertaken to test the hypothesis that patients with MHE are at higher
risk for keloid formation following excision of an exostosis. The study population consisted of a study group of 25 children and
adolescent cases of MHE randomly selected from a tumor database at our institution and a control group of 25 age-matched
cases of solitary exostosis (osteochondroma). All patients participated in a phone interview that consisted of questions
regarding the number of surgeries, recurrence of lesions, wound healing problems, keloid formation, keloid site and dimensions,
and any revision surgery. All patients with wound healing problems or suspected keloids were asked to take clinical pictures and
mail them in. Based on clinical criteria these cases were identified as keloids or non-keloids.
Results: 83 surgeries were performed in 25 patients with MHE for primary excision of their exostoses. 25 surgeries were
performed in 25 cases of solitary exostoses. 12 keloids formed in 7 patients in the MHE study group. No patients who
underwent excision of solitary exostoses formed keloids. Diagnosis of MHE was a statistically significant risk factor for
formation of keloids following surgery (p<.05). Maximal keloid width ranged from 5-10cm. Scar revision was performed in four
of the seven children with keloid formation with MHE, of whom two required additional scar revision procedures.
As a pediatric orthopaedic surgeon, Dr. Dormans has spent the majority of his career treating children with musculoskeletal
tumors and disorders of the spine. Over the years, one of Dr. Dormans’ goals was to conduct research that expounds the
etiology, process and optimal treatment of patients with congenital conditions, trauma, and other musculoskeletal conditions
through clinical studies and collaborative basic science research. Dr. Dormans serves on the Scientific and Medical Advisory
Board of the MHE Research Foundation. He sees about 15 children who suffer from MHE a week and 90% of these children
require surgery. Dr. Dormans’ has spent much of his career researching and studying musculoskeletal tumors and spinal
deformity conditions in children and he has published numerous publications on his life’s work.
In December 2008, Dr. Dormans moderated the first session on MHE at the 5th Annual International Pediatric Orthopaedic
Symposium. Dr. Dormans is the current president of the Pediatric Orthopaedic Society of North America (POSNA). Dr.
Dormans has had a great impact on the care of children with MHE. He has brought a global awareness to Multiple Hereditary
Exostoses and its great orthopaedic presence. His commitment to MHE Research has been and continues to be profound.
On behalf of the MHE Research Foundation, every family affected by MHE, the entire Orthopaedic community, we would like to
extend our eternal gratitude for his work, leadership and service to the MHE community.
Dr. Dormans and Dr. Hosalkar co- authored the standards of care chapter in the Connection Corner Guide to MHE/MO/HME Multiple Hereditary
Exostoses/Multiple Osteochondroma book.
tumors and disorders of the spine. Over the years, one of Dr. Dormans’ goals was to conduct research that expounds the
etiology, process and optimal treatment of patients with congenital conditions, trauma, and other musculoskeletal conditions
through clinical studies and collaborative basic science research. Dr. Dormans serves on the Scientific and Medical Advisory
Board of the MHE Research Foundation. He sees about 15 children who suffer from MHE a week and 90% of these children
require surgery. Dr. Dormans’ has spent much of his career researching and studying musculoskeletal tumors and spinal
deformity conditions in children and he has published numerous publications on his life’s work.
In December 2008, Dr. Dormans moderated the first session on MHE at the 5th Annual International Pediatric Orthopaedic
Symposium. Dr. Dormans is the current president of the Pediatric Orthopaedic Society of North America (POSNA). Dr.
Dormans has had a great impact on the care of children with MHE. He has brought a global awareness to Multiple Hereditary
Exostoses and its great orthopaedic presence. His commitment to MHE Research has been and continues to be profound.
On behalf of the MHE Research Foundation, every family affected by MHE, the entire Orthopaedic community, we would like to
extend our eternal gratitude for his work, leadership and service to the MHE community.
Dr. Dormans and Dr. Hosalkar co- authored the standards of care chapter in the Connection Corner Guide to MHE/MO/HME Multiple Hereditary
Exostoses/Multiple Osteochondroma book.
| Was held on September 13, 2009 during the FUNTASIA Research banquet John P. Dormans, M.D. was presented with the "The Humanitarian Scientific Achievement Award" along with the awarding of ~ New York City Council ~ PROCLAMATION ~ ~ New York State Senate ~ LEGISLATIVE RESOLUTION pdf link~ ~ The Borough of Brooklyn, City of New York. ~ CITATION pdf link ~ To read more about this event Click Here |
The Pediatric Orthopaedic Society of North America (POSNA) Presidential Transfer to John P. Dormans, M.D., during the POSNA
conference held May 2, 2008. This video starts with the chronicle of Dr. Dormans life and career given by Stephens Richards,
M.D., the 2008 out going President of POSNA followed by Dr. Dormans acceptance. FYI live video was taped about 30 seconds
after the audio starts. Our foundation would like to Thank Dr. Richards for announcing Dr. Dormans receiving our
"Humanitarian Scientific Achievement Award" during this video.
conference held May 2, 2008. This video starts with the chronicle of Dr. Dormans life and career given by Stephens Richards,
M.D., the 2008 out going President of POSNA followed by Dr. Dormans acceptance. FYI live video was taped about 30 seconds
after the audio starts. Our foundation would like to Thank Dr. Richards for announcing Dr. Dormans receiving our
"Humanitarian Scientific Achievement Award" during this video.
| Sarah Ziegler Vice President MHE Research Foundation, Dr. John P. Dormans, New York City Mayor Mayor Bloomberg, Craig A. Eaton Esq, President MHE Research Foundation taken during this event more pictures and video will be posted shortly |
Dec 3-7, 2008
5th Annual International Pediatric Orthopaedic Symposium (IPOS) presented by the American Academy of Orthopaedic
Surgeons (AAOS) and Pediatric Orthopaedic Society of North America (POSNA)
During this symposium there was a workshop held on Dec 5, 2008 relating to the surgical needs of children with MHE. This
session was moderated by Dr. Benjamin Alman. Our foundation would like to extend its thanks to all participating Orthopaedic
Faculty Dr. Dormans, Dr. Paley, Dr. Noonan, Dr. Gebhardt, Dr. Ippolito, Dr. Dimeglio who presented MHE / MO / HME.
Dec 2-5, 2009 held in Orlando Florida
6th International Pediatric Orthopaedic Symposium (IPOS)
If you are an Orthopaedic Surgeon and are interested in registering for this years IPOS meeting, there will be a session on Benign
& Malignant bone tumors moderated by Dr. Vernon Tolo presenting during this session are Dr. Alman, Dr. Crawford and
Dr. Dormans. A session will also be held on limb length inequality, diagnosis and management. Please Click Here for registration
information, presenters & other sessions beheld during IPOS
5th Annual International Pediatric Orthopaedic Symposium (IPOS) presented by the American Academy of Orthopaedic
Surgeons (AAOS) and Pediatric Orthopaedic Society of North America (POSNA)
During this symposium there was a workshop held on Dec 5, 2008 relating to the surgical needs of children with MHE. This
session was moderated by Dr. Benjamin Alman. Our foundation would like to extend its thanks to all participating Orthopaedic
Faculty Dr. Dormans, Dr. Paley, Dr. Noonan, Dr. Gebhardt, Dr. Ippolito, Dr. Dimeglio who presented MHE / MO / HME.
Dec 2-5, 2009 held in Orlando Florida
6th International Pediatric Orthopaedic Symposium (IPOS)
If you are an Orthopaedic Surgeon and are interested in registering for this years IPOS meeting, there will be a session on Benign
& Malignant bone tumors moderated by Dr. Vernon Tolo presenting during this session are Dr. Alman, Dr. Crawford and
Dr. Dormans. A session will also be held on limb length inequality, diagnosis and management. Please Click Here for registration
information, presenters & other sessions beheld during IPOS
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website, also linked for Patient Information on The Diseases Database a cross-referenced index of human disease, as well as the
Intute: health & life sciences a free online service providing access to the very best Web resources for education and research located in the UK
Click here to verify.# HON Conduct 282463 and is the patient support link on the US Government Genetics Home Reference (http://ghr.nlm.nih.gov)
website, also linked for Patient Information on The Diseases Database a cross-referenced index of human disease, as well as the
Intute: health & life sciences a free online service providing access to the very best Web resources for education and research located in the UK
The MHE Research Foundation is proud to be working with the EuroBoNeT consortium, a European Commission granted Network of Excellence for
studying the pathology and genetics of bone tumors.
studying the pathology and genetics of bone tumors.
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