| When trying to locate a Orthopaedics physician, you may want to ask how many cases of this disorder have he / she seen in there years of medical practice, this is a rare disorder and the more experience the better in most cases. |
| What is Multiple Hereditary Exostoses? |
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MHE / MO / HME is a genetic bone disorder in which benign cartilage-capped
bone tumors that grow outward from the metaphyses of long bones, growth
plates of long bones or from the surface of flat bones throughout the body.
These cartilage-capped bone tumors are called Exostoses / Osteochondroma
and may be sessile or pedunculated and vary widely in size and shape.
Pedunculated Exostoses / Osteochondroma is when a stalk is present, the
structure is called pedunculated. These have a Broccoli like appearance with
stalk and growth towards the end of the stalk.
Sessile Exostoses / Osteochondroma have a broad-base attachment to the
outer bone, called the "cortex". These have a lumpy / bumpy appearance
(When no stalk is present, these are called sessile)
These Exostoses / Osteochondroma's can cause numerous problems,
including: compression of peripheral nerves or blood vessels; irritation of
tendons and muscles resulting in pain and loss of motion; skeletal deformity;
short stature; limb length discrepancy; chronic pain and fatigue; mobility
issues; early onset arthritis; and an increased risk of developing
chondro-sarcoma (Life time risk of 2%-5% reported).
bone tumors that grow outward from the metaphyses of long bones, growth
plates of long bones or from the surface of flat bones throughout the body.
These cartilage-capped bone tumors are called Exostoses / Osteochondroma
and may be sessile or pedunculated and vary widely in size and shape.
Pedunculated Exostoses / Osteochondroma is when a stalk is present, the
structure is called pedunculated. These have a Broccoli like appearance with
stalk and growth towards the end of the stalk.
Sessile Exostoses / Osteochondroma have a broad-base attachment to the
outer bone, called the "cortex". These have a lumpy / bumpy appearance
(When no stalk is present, these are called sessile)
These Exostoses / Osteochondroma's can cause numerous problems,
including: compression of peripheral nerves or blood vessels; irritation of
tendons and muscles resulting in pain and loss of motion; skeletal deformity;
short stature; limb length discrepancy; chronic pain and fatigue; mobility
issues; early onset arthritis; and an increased risk of developing
chondro-sarcoma (Life time risk of 2%-5% reported).
If you are Physician or Genetic Counselor would a second opinion or assistance related to care, the physician can to email Sarah Ziegler
directly or sign into the physician registry. At that point the MHE Research Foundation will put the Physician / Genetic Counselor directly
in contact with a Physician or Geneticists that could help sort out the medical issue directly. This assistance is offered to medical
professional only. If you are a patient wanting a second opinion please use the doctor directories located on this website, if after you still
need assistance contact Sarah Ziegler.
directly or sign into the physician registry. At that point the MHE Research Foundation will put the Physician / Genetic Counselor directly
in contact with a Physician or Geneticists that could help sort out the medical issue directly. This assistance is offered to medical
professional only. If you are a patient wanting a second opinion please use the doctor directories located on this website, if after you still
need assistance contact Sarah Ziegler.
| Multiple Hereditary Exostoses ("MHE") also often referred to as Hereditary Multiple Exostoses ("HME") Multiple Osteochondroma ("MO") (''MO") is the preferred term used by the World Health Organization Further detailed Orthopaedic informational links are contained in the table below. |
It is not uncommon for MHE / MO / HME patients to undergo numerous surgical procedures throughout their lives to remove
painful or deforming Exostoses / Osteochondroma's and or to correct limb length discrepancies and improve range of motion.
Surgery, physical therapy and pain management are currently the only options available to MHE / MO / HME patients, but their
success varies from patient to patient and many struggle with pain, fatigue and mobility problems throughout their lives.
MHE / MO / HME is an autosomal dominant hereditary disorder.
This means that a patient with MHE / MO / MHE has a 50% chance of transmitting the disorder to his/her children. This is equal
for both male and female patients. Normally this disorder does not skip a generation
Most individuals with MHE / MO / HME have a parent who also has the condition, however, approximately 10%- 20% of
individuals with MHE / MO / HME have the condition as a result of a (de novo ) spontaneous mutation are thus the first person in
their family to be affected.
Abnormal scarring with keloid formation after osteochondroma excision in MHE has not been previously reported up until now.
Although this study has limited numbers, the results demonstrate a statistically significant correlation between keloid formation
and MHE. The risk for abnormal scarring and keloid formation should be discussed with all patients before surgery. Abnormal
Scarring With Keloid Formation After Osteochondroma Excision in Children With Multiple Hereditary Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007. Link to abstract
Some of the synonyms used to discribe this condition: Multiple Hereditary Exostoses (Exostosis); Multiple
Osteochondroma; Hereditary Multiple Exostoses; Osteochondromata; Multiple Carthaginous Exostoses (Exostosis);
Multiple Osteochondromatosis; Diaphyseal Aclasis; Bessel-Hagen disease; MHE / MO / HME
painful or deforming Exostoses / Osteochondroma's and or to correct limb length discrepancies and improve range of motion.
Surgery, physical therapy and pain management are currently the only options available to MHE / MO / HME patients, but their
success varies from patient to patient and many struggle with pain, fatigue and mobility problems throughout their lives.
MHE / MO / HME is an autosomal dominant hereditary disorder.
This means that a patient with MHE / MO / MHE has a 50% chance of transmitting the disorder to his/her children. This is equal
for both male and female patients. Normally this disorder does not skip a generation
Most individuals with MHE / MO / HME have a parent who also has the condition, however, approximately 10%- 20% of
individuals with MHE / MO / HME have the condition as a result of a (de novo ) spontaneous mutation are thus the first person in
their family to be affected.
Abnormal scarring with keloid formation after osteochondroma excision in MHE has not been previously reported up until now.
Although this study has limited numbers, the results demonstrate a statistically significant correlation between keloid formation
and MHE. The risk for abnormal scarring and keloid formation should be discussed with all patients before surgery. Abnormal
Scarring With Keloid Formation After Osteochondroma Excision in Children With Multiple Hereditary Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007. Link to abstract
Some of the synonyms used to discribe this condition: Multiple Hereditary Exostoses (Exostosis); Multiple
Osteochondroma; Hereditary Multiple Exostoses; Osteochondromata; Multiple Carthaginous Exostoses (Exostosis);
Multiple Osteochondromatosis; Diaphyseal Aclasis; Bessel-Hagen disease; MHE / MO / HME
Figure from J Bone Joint Surg Am.1994;76:986-992
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Click here to verify.# HON Conduct 282463 and is the patient support link on the US Government Genetics Home Reference (http://ghr.nlm.nih.gov)
website, also linked for Patient Information on The Diseases Database a cross-referenced index of human disease, as well as the
Intute: health & life sciences a free online service providing access to the very best Web resources for education and research located in the UK
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