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| When trying to locate a Orthopaedics physician, you may want to ask how many cases of this disorder have he / she seen in there years of medical practice, this is a rare disorder and the more experience the better in most cases. |
Multiple Hereditary Exostoses ("MHE") also often referred to as
Hereditary Multiple Exostoses ("HME")
Multiple Osteochondroma ("MO")
(''MO") is the preferred term used by the World Health Organization
Further detailed Orthopaedic information is contained in the GREEN Table Below.
MHE / MO / HME is a genetic bone disorder in which benign cartilage-capped bone tumors that grow
outward from the metaphyses of long bones, growth plates of long bones or from the surface of flat
bones throughout the body.
An Exostosis / Osteochondroma may be sessile or pedunculated.
Sessile Exostoses / Osteochondroma have a broad-based attachment to the cortex.
The pedunculated variants have a pedicle arising from the cortex that is usually directed away from
the adjacent growth plate.
The pedunculated form is more likely to irritate overlying soft tissue, such as tendons, and compress
peripheral nerves or vessels.
These Exostoses / Osteochondroma's can cause numerous problems, including: compression of
peripheral nerves or blood vessels; irritation of tendons and muscles resulting in pain and loss of
motion; skeletal deformity; short stature; limb length discrepancy; chronic pain and fatigue; mobility
issues; early onset arthritis; and an increased risk of developing chondro-sarcoma (Life time risk of
2%-5% reported).
It is not uncommon for MHE / MO / HME patients to undergo numerous surgical procedures
throughout their lives to remove painful or deforming Exostoses / Osteochondroma's and or to
correct limb length discrepancies and improve range of motion.
Surgery, physical therapy and pain management are currently the only options available to MHE / MO
/ HME patients, but their success varies from patient to patient and many struggle with pain, fatigue
and mobility problems throughout their lives.
MHE / MO / HME is an autosomal dominant hereditary disorder.
This means that a patient with MHE / MO / MHE has a 50% chance of transmitting the disorder to
his/her children. This is equal for both male and female patients. Normally this disorder does not skip
a generation
Most individuals with MHE / MO / HME have a parent who also has the condition, however,
approximately 10%- 20% of individuals with MHE / MO / HME have the condition as a result of a (de
novo ) spontaneous mutation are thus the first person in their family to be affected.
Abnormal scarring with keloid formation after osteochondroma excision in MHE has not been
previously reported up until now. Although this study has limited numbers, the results demonstrate
a statistically significant correlation between keloid formation and MHE. The risk for abnormal scarring
and keloid formation should be discussed with all patients before surgery. Abnormal Scarring With
Keloid Formation After Osteochondroma Excision in Children With Multiple Hereditary
Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007. Link to abstract
Some of the synonyms used to discribe this condition: Multiple Hereditary Exostoses
(Exostosis); Multiple Osteochondroma; Hereditary Multiple Exostoses Osteochondromata;
Multiple Carthaginous Exostoses (Exostosis); Multiple Osteochondromatosis; Diaphyseal
Aclasis; MHE / MO / HME
Hereditary Multiple Exostoses ("HME")
Multiple Osteochondroma ("MO")
(''MO") is the preferred term used by the World Health Organization
Further detailed Orthopaedic information is contained in the GREEN Table Below.
MHE / MO / HME is a genetic bone disorder in which benign cartilage-capped bone tumors that grow
outward from the metaphyses of long bones, growth plates of long bones or from the surface of flat
bones throughout the body.
An Exostosis / Osteochondroma may be sessile or pedunculated.
Sessile Exostoses / Osteochondroma have a broad-based attachment to the cortex.
The pedunculated variants have a pedicle arising from the cortex that is usually directed away from
the adjacent growth plate.
The pedunculated form is more likely to irritate overlying soft tissue, such as tendons, and compress
peripheral nerves or vessels.
These Exostoses / Osteochondroma's can cause numerous problems, including: compression of
peripheral nerves or blood vessels; irritation of tendons and muscles resulting in pain and loss of
motion; skeletal deformity; short stature; limb length discrepancy; chronic pain and fatigue; mobility
issues; early onset arthritis; and an increased risk of developing chondro-sarcoma (Life time risk of
2%-5% reported).
It is not uncommon for MHE / MO / HME patients to undergo numerous surgical procedures
throughout their lives to remove painful or deforming Exostoses / Osteochondroma's and or to
correct limb length discrepancies and improve range of motion.
Surgery, physical therapy and pain management are currently the only options available to MHE / MO
/ HME patients, but their success varies from patient to patient and many struggle with pain, fatigue
and mobility problems throughout their lives.
MHE / MO / HME is an autosomal dominant hereditary disorder.
This means that a patient with MHE / MO / MHE has a 50% chance of transmitting the disorder to
his/her children. This is equal for both male and female patients. Normally this disorder does not skip
a generation
Most individuals with MHE / MO / HME have a parent who also has the condition, however,
approximately 10%- 20% of individuals with MHE / MO / HME have the condition as a result of a (de
novo ) spontaneous mutation are thus the first person in their family to be affected.
Abnormal scarring with keloid formation after osteochondroma excision in MHE has not been
previously reported up until now. Although this study has limited numbers, the results demonstrate
a statistically significant correlation between keloid formation and MHE. The risk for abnormal scarring
and keloid formation should be discussed with all patients before surgery. Abnormal Scarring With
Keloid Formation After Osteochondroma Excision in Children With Multiple Hereditary
Exostoses.
Journal of Pediatric Orthopaedics. 27(3):333-337, April/May 2007. Link to abstract
Some of the synonyms used to discribe this condition: Multiple Hereditary Exostoses
(Exostosis); Multiple Osteochondroma; Hereditary Multiple Exostoses Osteochondromata;
Multiple Carthaginous Exostoses (Exostosis); Multiple Osteochondromatosis; Diaphyseal
Aclasis; MHE / MO / HME
|
If you are Physician or Genetic Counselor would a second opinion or assistance related to care, the physician
can to email Sarah Ziegler directly or sign into the physician registry. At that point the MHE Research
Foundation will put the Physician / Genetic Counselor directly in contact with a Physician or Geneticists that
could help sort out the medical issue directly. This assistance is offered to medical professional only. If you are
a patient wanting a second opinion please use the doctor directories located on this website, if after you still
need assistance contact Sarah Ziegler,
can to email Sarah Ziegler directly or sign into the physician registry. At that point the MHE Research
Foundation will put the Physician / Genetic Counselor directly in contact with a Physician or Geneticists that
could help sort out the medical issue directly. This assistance is offered to medical professional only. If you are
a patient wanting a second opinion please use the doctor directories located on this website, if after you still
need assistance contact Sarah Ziegler,
| What is Multiple Hereditary Exostoses? |
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This website is regularly reviewed by members of the Scientific and Medical Advisory Board of the MHE Research Foundation.
Disclaimer: While many find the information useful, it is in no way a substitute for professional medical care.
The information provided here is for educational and informational purposes only. This website does not engage in the practice
of medicine. In all cases we recommend that you consult your own physician regarding any course of treatment or medicine.
The information provided here is for educational and informational purposes only. This website does not engage in the practice
of medicine. In all cases we recommend that you consult your own physician regarding any course of treatment or medicine.
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This web page was updated last on 2/20/08, 4:00 pm Eastern time
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By the Health On the Net Foundation. Click here to verify.# HON Conduct 282463 and is linked on the NIH
National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
By the Health On the Net Foundation. Click here to verify.# HON Conduct 282463 and is linked on the NIH
National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
The MHE Research Foundation is proud to be working with the EuroBoNeT consortium, a European Commission
granted Network of Excellence for studying the pathology and genetics of bone tumors.
granted Network of Excellence for studying the pathology and genetics of bone tumors.
