| Dr. Hecht's research |
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Dr. Hecht serves on the Scientific and Medical Advisory Board of the MHE Research Foundation
Research authored by Dr. Hecht
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List of Publications via PubMed
(NIH National Library of Medicine)
Research authored by Dr. Hecht
Click the tab and a window will appear.
List of Publications via PubMed
(NIH National Library of Medicine)
Questions to the Scientific & Medical Advisory Board,
Please use the contact Scientific & Medical Advisory Board Tab or you may email directly
AdvisoryBoard@mheresearchfoundation.org
Please use the contact Scientific & Medical Advisory Board Tab or you may email directly
AdvisoryBoard@mheresearchfoundation.org
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Have a Question or Comments for the Board of Directors,
Please use the contact Board of Directors Tab or General enquiries can be emailed to
Boardofdirectors@mheresearchfoundation.org
Please use the contact Board of Directors Tab or General enquiries can be emailed to
Boardofdirectors@mheresearchfoundation.org
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Jacqueline Hecht, Ph.D. is a board certified Medical Geneticist specializing in disorders related to bone growth. She provides
diagnostic and genetic counseling to patients and families with a variety of skeletal disorders. She became interested in Multiple
Hereditary Exostoses (MHE) during the 1980s and as such is one of only a handful of professionals who knew anything about
this condition. She directed her research towards locating the genes that caused MHE, eventually locating the EXT1 gene on
chromosome 8 and later, the EXT2 on chromosome 11. In 1995, she published one of the first studies describing the natural
history of MHE as well as a publication describing the development of chondrosarcoma to MHE.
In 1999, Sarah Ziegler contacted Dr. Hecht requesting her assistance with our organization’s efforts. Without hesitation, she
began working with us. Our first steps were to inform MHE families that tumor and blood samples were needed to expand her
research. As our children had surgery, research sample collection boxes were sent to parents and given to Orthopedic
surgeons who would return the samples after informed consent. In 2002, Dr. Hecht was instrumental in bringing about the
First International MHE Research Conference and published that heparan sulfate abnormalities were present in exostosis
growth plates, confirming that the mutations in EXT1 and EXT2 genes affect the production of proteins that require heparan
sulfate. Dr. Hecht also demonstrated that MHE is associated with aberrant chondrocyte proliferation and the development of
multiple bony bumps at the ends of all the long bones.
Dr. Hecht worked tirelessly with Sarah to take genetic testing of the EXT genes out of the research laboratories making it
accessible for clinical use. Health care professionals can now readily order this testing for families. In 2005, she co-organized
the Second International MHE Research Conference. In discussions with Dr. Hecht, we pointed out that pain is a huge issue for
MHE patients and was unrecognized and untreated. Together, we undertook a study to determine the extent and type of pain
in MHE and the results were published in the Journal of Pediatric Orthopaedics. Dr. Hecht also wrote the chapter on the
genetics of MHE in the Connection Corner Guide book that appears on our website and is distributed to families and physicians.
Dr. Hecht has written more than 160 peer reviewed scientific publications, 14 of which have been on MHE.
Dr. Hecht obtained her M.S. in Human Genetics and Genetic Counseling at University of Colorado Medical Center Denver in
1976, and her Ph.D. in Epidemiology at the University of Texas School of Public Health in 1988. She is currently a Professor in
the Department of Pediatrics and in the Graduate School of Biomedical Sciences at The University of Texas Medical School. She
is Director of the Pediatric Research Center and Vice Chair for Research in the Department of Pediatrics. Dr. Hecht is a reviewer
for multiple medical journals including the American Journal of Medical Genetics, American Journal of Human Genetics, Journal of
Epidemiology and Journal of Orthopedic Research. She has authored/co-authored 22 book chapters. She has served on
multiple study sections for the National Institute of Health including Orthopedics & Musculoskeletal Study Section. Her research
focuses on understanding the underlying pathologic mechanisms that affect bone growth. She has been invited to present her
research around the world at many Genetic/Scientific Research Society conferences.
diagnostic and genetic counseling to patients and families with a variety of skeletal disorders. She became interested in Multiple
Hereditary Exostoses (MHE) during the 1980s and as such is one of only a handful of professionals who knew anything about
this condition. She directed her research towards locating the genes that caused MHE, eventually locating the EXT1 gene on
chromosome 8 and later, the EXT2 on chromosome 11. In 1995, she published one of the first studies describing the natural
history of MHE as well as a publication describing the development of chondrosarcoma to MHE.
In 1999, Sarah Ziegler contacted Dr. Hecht requesting her assistance with our organization’s efforts. Without hesitation, she
began working with us. Our first steps were to inform MHE families that tumor and blood samples were needed to expand her
research. As our children had surgery, research sample collection boxes were sent to parents and given to Orthopedic
surgeons who would return the samples after informed consent. In 2002, Dr. Hecht was instrumental in bringing about the
First International MHE Research Conference and published that heparan sulfate abnormalities were present in exostosis
growth plates, confirming that the mutations in EXT1 and EXT2 genes affect the production of proteins that require heparan
sulfate. Dr. Hecht also demonstrated that MHE is associated with aberrant chondrocyte proliferation and the development of
multiple bony bumps at the ends of all the long bones.
Dr. Hecht worked tirelessly with Sarah to take genetic testing of the EXT genes out of the research laboratories making it
accessible for clinical use. Health care professionals can now readily order this testing for families. In 2005, she co-organized
the Second International MHE Research Conference. In discussions with Dr. Hecht, we pointed out that pain is a huge issue for
MHE patients and was unrecognized and untreated. Together, we undertook a study to determine the extent and type of pain
in MHE and the results were published in the Journal of Pediatric Orthopaedics. Dr. Hecht also wrote the chapter on the
genetics of MHE in the Connection Corner Guide book that appears on our website and is distributed to families and physicians.
Dr. Hecht has written more than 160 peer reviewed scientific publications, 14 of which have been on MHE.
Dr. Hecht obtained her M.S. in Human Genetics and Genetic Counseling at University of Colorado Medical Center Denver in
1976, and her Ph.D. in Epidemiology at the University of Texas School of Public Health in 1988. She is currently a Professor in
the Department of Pediatrics and in the Graduate School of Biomedical Sciences at The University of Texas Medical School. She
is Director of the Pediatric Research Center and Vice Chair for Research in the Department of Pediatrics. Dr. Hecht is a reviewer
for multiple medical journals including the American Journal of Medical Genetics, American Journal of Human Genetics, Journal of
Epidemiology and Journal of Orthopedic Research. She has authored/co-authored 22 book chapters. She has served on
multiple study sections for the National Institute of Health including Orthopedics & Musculoskeletal Study Section. Her research
focuses on understanding the underlying pathologic mechanisms that affect bone growth. She has been invited to present her
research around the world at many Genetic/Scientific Research Society conferences.
| Jacqueline T. Hecht, Ph.D. Director of Pediatric Research Center at The University of Texas Medical School Has been awarded the 2011 MHE Research Foundation "The REACH Rsearch Award" She will also be presented the following awards by members of the U. S. Congress ~ N. Y. State Senate The Borough of Brooklyn, City of New York. CITATIONS PROCLAMATIONS CERTIFICATES OF RECOGNITION These awards will be presented during the FUNTASIA Research Banquet to be held Sunday Sept, 25,2011 TO READ MORE ABOUT THIS EVENT OR TO ATTEND CLICK HERE |
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website, also linked for Patient Information on The Diseases Database a cross-referenced index of human disease, as well as the
Intute: health & life sciences a free online service providing access to the very best Web resources for education and research located in the UK
Click here to verify.# HON Conduct 282463 and is the patient support link on the US Government Genetics Home Reference (http://ghr.nlm.nih.gov)
website, also linked for Patient Information on The Diseases Database a cross-referenced index of human disease, as well as the
Intute: health & life sciences a free online service providing access to the very best Web resources for education and research located in the UK
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The MHE Research Foundation is proud to be an affiliate of the Society For Glycobiology
| Wings of HOPE as we REACH for the CURE to Multiple Hereditary Exostoses Syndrome Multiple Osteochondroma Syndrome |
Jacqueline T. Hecht, PH.D.
