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Professor Developmental Neurobiology Program,
The Burnham Institute, La Jolla, CA
The Burnham Institute, La Jolla, CA
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Senior Research Biologist,
Merck Research Laboratories, Rahway, NJ
Merck Research Laboratories, Rahway, NJ
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"REACH Research Award" to read more Click Here
Dr. Stickens spent over ten years of his life as a graduate student at UTSW as well as his
postdoctoral training at UCSF in the field of EXT genes and has contributed substantially to the
understanding of the pathogenesis of hereditary multiple exostoses.
Dr. Stickens identified the EXT2 gene, and in so doing, has helped define a new family of putative
tumor suppressor genes. Moreover, he went on to characterize that gene for its normal role in
development and pursued the question of how a loss of function for this gene product participates
in disregulated bone development.
Dr. Stickens was able to create a EXT2 knock-out mouse that formed exostoses and thus recreated
the human phenotype. The genetically engineered mouse he created has proved to be a very
valuable model that provided profound insights into both disease mechanism and basic biological
processes. These EXT2 knock-out mice are used by many scientists as a tool for further
understanding the underlying causes of MHE.
Dr. Stickens spent over ten years of his life as a graduate student at UTSW as well as his
postdoctoral training at UCSF in the field of EXT genes and has contributed substantially to the
understanding of the pathogenesis of hereditary multiple exostoses.
Dr. Stickens identified the EXT2 gene, and in so doing, has helped define a new family of putative
tumor suppressor genes. Moreover, he went on to characterize that gene for its normal role in
development and pursued the question of how a loss of function for this gene product participates
in disregulated bone development.
Dr. Stickens was able to create a EXT2 knock-out mouse that formed exostoses and thus recreated
the human phenotype. The genetically engineered mouse he created has proved to be a very
valuable model that provided profound insights into both disease mechanism and basic biological
processes. These EXT2 knock-out mice are used by many scientists as a tool for further
understanding the underlying causes of MHE.
| There is NO treatment / cure for MHE now, but research is starting to make great progress into understanding the etiology of MHE. Researchers are just at the point where together with the support of this event and others, they can make major inroads toward better diagnosis, treatment, and possible cure. |
| During this banquet "The Humanitarian Scientific Achievement Award" was presented to Dr. Yu Yamaguchi. & " REACH Research Award" was presented to Dr. Dominique Stickens. Both Researchers were also presented the following awards by members of the U. S. Congress ~ N. Y. State Senate The Borough of Brooklyn, City of New York. CITATIONS PROCLAMATIONS CERTIFICATES OF RECOGNITION |
Both Dr. Yamaguchi & Dr. Stickens are members of the MHE Research Foundations Scientific and
Medical Advisory Board and their years of service are greatly appreciated by our foundation and by
all who suffer the devastating affects of MHE. Both researchers will be organizing the next
International MHE Research Conference, along with the MHE Research Foundation and will be held in
Orlando FL July 8-11, 2009. Without the efforts of these two outstanding researchers, MHE research
would not be where it is today.
Medical Advisory Board and their years of service are greatly appreciated by our foundation and by
all who suffer the devastating affects of MHE. Both researchers will be organizing the next
International MHE Research Conference, along with the MHE Research Foundation and will be held in
Orlando FL July 8-11, 2009. Without the efforts of these two outstanding researchers, MHE research
would not be where it is today.
Arch Angel Productions: Donation of photography
Comptime Print & Copy Center: All printing services used by the MHE Research Foundation
are generously donated by Comptime Print & Copy Center: 385 North Franklin Turnpike • Ramsey,
NJ 07446 • Phone: (201) 760-2400
• Fax: (201) 760-9140
Reich Paper: Duke Reich President, Donation of the spectacular paper used in printing the
invitations for this event.
7518 Third Avenue • Brooklyn, NY 11209
Victory Entertainment: Victor & Jack Spadaro, Donation of the DJ for our event.
•1786 SHEEPSHEAD BAY ROAD • BROOKLYN, NY 11209 • Phone: (718) 648-8001
Comptime Print & Copy Center: All printing services used by the MHE Research Foundation
are generously donated by Comptime Print & Copy Center: 385 North Franklin Turnpike • Ramsey,
NJ 07446 • Phone: (201) 760-2400
• Fax: (201) 760-9140
Reich Paper: Duke Reich President, Donation of the spectacular paper used in printing the
invitations for this event.
7518 Third Avenue • Brooklyn, NY 11209
Victory Entertainment: Victor & Jack Spadaro, Donation of the DJ for our event.
•1786 SHEEPSHEAD BAY ROAD • BROOKLYN, NY 11209 • Phone: (718) 648-8001
| The MHE Research Foundation would like to Thank the following companies for their donations to this event. |
To read the The Burnham Institute Press Release Click Here
"The Humanitarian Scientific Achievement Award" to read more Click Here
To read Dr. Yamaguchi speech Click Here
Dr. Yamaguchi created a conditional EXT1 knockout mouse model. These conditional EXT1
knockout mice are being used for genetic studies to figure out how the deficiency of EXT1/heparan
sulfate causes MHE. These conditional knockout mice, which allow knocking out EXT1 at the site
and time of researchers' desire, are very useful for diverse studies on the function of EXT1/heparan
sulfate.
Dr. Yamaguchi and his lab have been able to distribute these mice to more than 20 laboratories
around the world (US, Europe, and Japan) to help studies by other MHE investigators. Using this
model system, Dr. Yamaguchi has demonstrated that mutations of EXT1 influence not only bones
but also the nervous system. Although frequently ignored in the clinical front, MHE patients tend to
have some mental, neurological, and muscular symptoms. Such symptoms include: mild social
interaction deficits, heightened sensitivities to sensory stimulation, difficulties to concentrate, and
muscle weakness. Dr. Yamaguchi believes these neurological symptoms can be explained by the
deficiency of heparan sulfate in nerve cells. Indeed, recent analysis of knockout mouse behavior has
revealed that these mice have deficits in certain aspects of learning and the levels of fear/anxiety, as
well as alterations in nerve cell wiring.
In addition, Dr. Yamaguchi has recently discovered that knockout of EXT1 in stem cells that
destined to become bones and cartilage causes severe bone abnormalities. These findings have
provided us with a new insight into the reason why MHE patients frequently associate a variety of
symptoms in addition to exostosis/osteochondroma formation, and suggests potential novel MHE
treatment paradigms.
"The Humanitarian Scientific Achievement Award" to read more Click Here
To read Dr. Yamaguchi speech Click Here
Dr. Yamaguchi created a conditional EXT1 knockout mouse model. These conditional EXT1
knockout mice are being used for genetic studies to figure out how the deficiency of EXT1/heparan
sulfate causes MHE. These conditional knockout mice, which allow knocking out EXT1 at the site
and time of researchers' desire, are very useful for diverse studies on the function of EXT1/heparan
sulfate.
Dr. Yamaguchi and his lab have been able to distribute these mice to more than 20 laboratories
around the world (US, Europe, and Japan) to help studies by other MHE investigators. Using this
model system, Dr. Yamaguchi has demonstrated that mutations of EXT1 influence not only bones
but also the nervous system. Although frequently ignored in the clinical front, MHE patients tend to
have some mental, neurological, and muscular symptoms. Such symptoms include: mild social
interaction deficits, heightened sensitivities to sensory stimulation, difficulties to concentrate, and
muscle weakness. Dr. Yamaguchi believes these neurological symptoms can be explained by the
deficiency of heparan sulfate in nerve cells. Indeed, recent analysis of knockout mouse behavior has
revealed that these mice have deficits in certain aspects of learning and the levels of fear/anxiety, as
well as alterations in nerve cell wiring.
In addition, Dr. Yamaguchi has recently discovered that knockout of EXT1 in stem cells that
destined to become bones and cartilage causes severe bone abnormalities. These findings have
provided us with a new insight into the reason why MHE patients frequently associate a variety of
symptoms in addition to exostosis/osteochondroma formation, and suggests potential novel MHE
treatment paradigms.
| FUNTASIA Journal book 2007 (PDF) Companies & Individuals Gifts for the BEAUTIFUL BASKETS Platinum ad (Full page) Gold ad (Half page) Silver ad (Quarter page) |
| *Research Banquet* ... Part of the Magic of Giving! ...Part of Finding the Cure!!! Held On SUNDAY, SEPTEMBER 30, 2007 at Gargiulo’s Restaurant 2911 WEST 15TH Street Coney Island, Brooklyn, NY 11224 www.gargiulos.com |
Dan & Son Bobby Caputo, David Brooks, Craig & Son Vincent Eaton, Yu Yamaguchi M.D.,Ph.D.,
Susan Eaton, Dominique Stickens, Ph.D.Sarah & Son Robert Ziegler, Suzanne Caputo
Susan Eaton, Dominique Stickens, Ph.D.Sarah & Son Robert Ziegler, Suzanne Caputo
Craig A. Eaton President, Dr. Stickens,
N. Y. State Senator Senator Martin J. Golden,
Board of Director Susan Eaton, Dr. Yamaguchi,
Sarah Ziegler Vice President
N. Y. State Senator Senator Martin J. Golden,
Board of Director Susan Eaton, Dr. Yamaguchi,
Sarah Ziegler Vice President
Dr. Stickens,
N. Y. State Senator Senator Martin J. Golden,
Dr. Yamaguchi,
Sarah Ziegler Vice President & National Director of Research
N. Y. State Senator Senator Martin J. Golden,
Dr. Yamaguchi,
Sarah Ziegler Vice President & National Director of Research
N. Y. State Senator Senator Martin J. Golden,
President Craig A. Eaton Esq, Dr. Stickens,
Board of Director Susan Eaton, Dr. Yamaguchi
President Craig A. Eaton Esq, Dr. Stickens,
Board of Director Susan Eaton, Dr. Yamaguchi
Craig A. Eaton President, Dr. Stickens, Sarah Ziegler Vice President,
Dr. Yamaguchi, Board of Director Susan Eaton
Dr. Yamaguchi, Board of Director Susan Eaton
Craig & Susan Eaton
| Sarah Ziegler To read Sarah's total written speech Click Here |
Dr. Stickens
Susan Eaton
The power of the spoken word on behalf of all who suffer from Multiple Hereditary Exostoses.
|
Foundation Board of Directors with their children, honorees and guests
To view the video of President, Craig A. Eaton's speech and the speech by Senator Martin J. Golden Click Here
To view the video of Director of Fundraising, Susan Eaton's speech Click Here
To view the video of Vice President & National Director of Research, Sarah Ziegler speech Click Here
To view the video presentation of the REACH Research Award and Dr. Stickens speech Click Here
To view the video presentation of the Humanitarian Scientific Achievement Award and Dr.Yamaguci's
speech.Click Here
To view the video of Director of Fundraising, Susan Eaton's speech Click Here
To view the video of Vice President & National Director of Research, Sarah Ziegler speech Click Here
To view the video presentation of the REACH Research Award and Dr. Stickens speech Click Here
To view the video presentation of the Humanitarian Scientific Achievement Award and Dr.Yamaguci's
speech.Click Here
This website is regularly reviewed by members of the Scientific and Medical Advisory Board of the MHE Research Foundation.
Disclaimer: While many find the information useful, it is in no way a substitute for professional medical care.
The information provided here is for educational and informational purposes only. This website does not engage in the practice
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This web page was updated last on 2/20/08, 4:00 pm Eastern time
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The MHE Research Foundation, we comply with the HONcode standard for health trust worthy information:
By the Health On the Net Foundation. Click here to verify.# HON Conduct 282463 and is linked on the NIH
National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
By the Health On the Net Foundation. Click here to verify.# HON Conduct 282463 and is linked on the NIH
National Library of Medicine, Directory of Health Organizations (SIS) website, as well as the link for Patient
Information on The Diseases Database a cross-referenced index of human disease, and the Intute: health & life
sciences a free online service providing access to the very best Web resources for education and research
located in the UK
The MHE Research Foundation is proud to be working with the EuroBoNeT consortium, a European Commission
granted Network of Excellence for studying the pathology and genetics of bone tumors.
granted Network of Excellence for studying the pathology and genetics of bone tumors.
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